| http://purl.uniprot.org/citations/21209924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21209924 | http://www.w3.org/2000/01/rdf-schema#comment | "To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations at template A/T and at least a fraction of G/C transversions. In contrast to A/T mutations which depend on PCNA ubiquitination, it remains unclear how G/C transversions are regulated during SHM. Several lines of evidence indicate a mechanistic link between the Fanconi Anemia (FA) pathway and TLS. To investigate the contribution of the FA pathway in SHM we analyzed FancG-deficient B cells. B cells deficient for FancG, an essential member of the FA core complex, were hypersensitive to treatment with cross-linking agents. However, the frequencies and nucleotide exchange spectra of SHM remained comparable between wild-type and FancG-deficient B cells. These data indicate that the FA pathway is not involved in regulating the outcome of SHM in mammals. In addition, the FA pathway appears dispensable for class switch recombination."xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0015236"xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/author | "Jacobs H."xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/author | "van den Berk P.C."xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/author | "Krijger P.H."xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/author | "Wit N."xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/pages | "e15236"xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/title | "The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination."xsd:string |
| http://purl.uniprot.org/citations/21209924 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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