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http://purl.uniprot.org/citations/21211272http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21211272http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the expression and its clinical significance of estrogen receptor (ERα) and phosphorylated estrogen receptor (p-ERα) in patients with hepatocellular carcinoma. The associations between ERα, p-ERα and IL-6 were also analyzed.

Methods

Immunohistochemistry was used to detect the expression of ERα, p-ERα and IL-6 in tumor tissues from 77 cases with hepatocellular carcinoma. The relations between ERα and the clinical pathological parameters and prognosis were also analyzed.

Results

The positive rates of ERα, p-ERα and IL-6 in hepatocellular carcinoma were 39.0% (30/77), 45.4% (35/77) and 72.7% (56/77), respectively. The expression of ERα and p-ERα were negatively correlated with the expression of IL-6 (r=-0.468, P<0.01; r=-0.370, P<0.01, respectively). The positive rate of ERα in patients with tumor size≤5 cm, serum level of alpha-fetoprotein<400 µg/L, with complete encapsulation and non-microvascular invasion was significantly higher than those with tumor size>5 cm, serum level of alpha-fetoprotein≥400 µg/L, non-complete encapsulation and with microvascular invasion (all P<0.05). The overall survival rates of ERα-positive and ERα-negative patients were 66.7% and 23.4% (P<0.05). And the disease-free survival rates of ERα-positive and ERα-negative patients were 83.3% and 57.4% (P<0.05).

Conclusions

The tumor biological features of ERα-positive patients are better than that of ERα-negative patients. The role of ERα in hepatocellular carcinoma may be related to IL-6 level."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Wang Y.C."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Han S.J."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Zhang C.H."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Xu G.L."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Liu W.B."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Li J.S."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Ma J.L."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Ren W.H."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Ge Y.S."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/author"Jia W.D."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/name"Zhonghua Wai Ke Za Zhi"xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/pages"1875-1880"xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/title"[Expression of estrogen receptor alpha in hepatitis B-related hepatocellular carcinoma and its clinical significance]."xsd:string
http://purl.uniprot.org/citations/21211272http://purl.uniprot.org/core/volume"48"xsd:string
http://purl.uniprot.org/citations/21211272http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21211272
http://purl.uniprot.org/citations/21211272http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21211272
http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-21211272http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21211272
http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-21211272http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21211272
http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-21211272http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21211272
http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-21211272http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21211272
http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-21211272http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21211272
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