| http://purl.uniprot.org/citations/21213002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21213002 | http://www.w3.org/2000/01/rdf-schema#comment | "The human IMPA2 gene encoding myo-inositol monophosphatase 2 is highly implicated with bipolar disorder but the substrates and the reaction mechanism of myo-inositol monophosphatase 2 have not been well elucidated.9 In the present study, we constructed 3D models of three- and two-Mg(2+)-ion bound myo-inositol monophosphatase 2, and studied substrate-binding manners using the docking program AutoDock3. The subsequent study showed that the three-metal-ion model could interact with myo-inositol monophosphates, as follows: The phosphate moiety coordinated three Mg(2+) ions, and the inositol ring formed hydrogen bonds with the amino acids conserved in the family. Furthermore, the OH group vicinal to the phosphate group formed a hydrogen bond with a non-bridging oxygen atom of the phosphate. These interactions have been proposed as crucial for forming the transitional state, bipyramidal structure in the bovine myo-inositol monophosphatase. We therefore propose that the human myo-inositol monophosphatase 2 interacts with myo-inositol monophosphates in the three-metal-ion bound form, and proceeds the dephosphorylation through the three-metal-ion theory."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00894-010-0937-8"xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Fujita N."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Kikuchi T."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Yoshikawa T."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Ohnishi T."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Kobayashi R."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Fujita S."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Okuda S."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Fukuno S."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/author | "Furuta D."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/name | "J Mol Model"xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/pages | "2559-2567"xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/title | "In silico study on the substrate binding manner in human myo-inositol monophosphatase 2."xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/21213002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21213002 |
| http://purl.uniprot.org/citations/21213002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21213002 |
| http://purl.uniprot.org/uniprot/#_O14732-mappedCitation-21213002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21213002 |
| http://purl.uniprot.org/uniprot/#_Q6PIP6-mappedCitation-21213002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21213002 |
| http://purl.uniprot.org/uniprot/Q6PIP6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21213002 |
| http://purl.uniprot.org/uniprot/O14732 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21213002 |