| http://purl.uniprot.org/citations/2121370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2121370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2121370 | http://www.w3.org/2000/01/rdf-schema#comment | "The neurofibromatosis type 1 (NF1) protein contains a region of significant sequence similarity to ras p21 GTPase-activating protein (GAP) and the yeast IRA1 gene product. A fragment of NF1 cDNA encoding the GAP-related domain (NF1 GRD) was expressed, immunoaffinity purified, and assayed for effects on N-ras p21 GTPase activity. The GTPase of wild-type ras p21 was stimulated by NF1 GRD, but oncogenic mutants of ras p21 (Asp-12 and Val-12) were unaffected, and the GTPase of an effector mutant (Ala-38) was only weakly stimulated. NF1 GRD also down-regulated RAS function in S. cerevisiae. The affinity of NF1 GRD for ras p21 was estimated to be 250 nM: this is more than 20-fold higher than the affinity of GAP for ras p21. However, its specific activity was about 30 times lower. These kinetic measurements suggest that NF1 may be a significant regulator of ras p21 activity, particularly at low ras p21 concentrations."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(90)90150-d"xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(90)90150-d"xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Clark R."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Clark R."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "McCormick F."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "McCormick F."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Viskochil D."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Viskochil D."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Innis M."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Innis M."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Bollag G."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Bollag G."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "O'Connell P."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "O'Connell P."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "McCabe P.C."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "McCabe P.C."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Haubruck H."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Haubruck H."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Martin G.A."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Martin G.A."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Conroy L."xsd:string |
| http://purl.uniprot.org/citations/2121370 | http://purl.uniprot.org/core/author | "Conroy L."xsd:string |