| http://purl.uniprot.org/citations/21215703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21215703 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been proposed that an aggressive secondary cancer stem cell population arises from a primary cancer stem cell population through acquisition of additional genetic mutations and drives cancer progression. Overexpression of Polycomb protein EZH2, essential in stem cell self-renewal, has been linked to breast cancer progression. However, critical mechanism linking increased EZH2 expression to BTIC (breast tumor initiating cell) regulation and cancer progression remains unclear. Here, we identify a mechanism in which EZH2 expression-mediated downregulation of DNA damage repair leads to accumulation of recurrent RAF1 gene amplification in BTICs, which activates p-ERK-β-catenin signaling to promote BTIC expansion. We further reveal that AZD6244, a clinical trial drug that inhibits RAF1-ERK signaling, could prevent breast cancer progression by eliminating BTICs."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2010.10.035"xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Chang C.J."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Xia W."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Yang J.Y."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Chen C.T."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Hortobagyi G.N."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Hsu J.M."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Chao C.H."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/author | "Woodward W.A."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/pages | "86-100"xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/title | "EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/21215703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21215703 |
| http://purl.uniprot.org/citations/21215703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21215703 |
| http://purl.uniprot.org/uniprot/#_F2YMM1-mappedCitation-21215703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21215703 |
| http://purl.uniprot.org/uniprot/#_A0A090N8E9-mappedCitation-21215703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21215703 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L5-mappedCitation-21215703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21215703 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z559-mappedCitation-21215703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21215703 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-21215703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21215703 |