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http://purl.uniprot.org/citations/21219832http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21219832http://www.w3.org/2000/01/rdf-schema#comment"

Background and objective

uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC).

Methods

Expressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed.

Results

Negative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lymph node metastasis (P=0.017). Adenocarcinoma patients with high expression of uPA or with high expression of both ET-1 and uPA had the longer survival time (P=0.007 and 0.016).

Conclusions

Detection of uPA and ET-1 protein levels might contribute to the prognosis evaluation of NSCLC."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.org/dc/terms/identifier"doi:10.3779/j.issn.1009-3419.2011.01.10"xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Jiang Y."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Wang M."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Shi Z."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Zhang S."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Xu X."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Wang B."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/author"Shang L."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/name"Zhongguo Fei Ai Za Zhi"xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/pages"49-53"xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/title"[Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer]."xsd:string
http://purl.uniprot.org/citations/21219832http://purl.uniprot.org/core/volume"14"xsd:string
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