| http://purl.uniprot.org/citations/21220424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21220424 | http://www.w3.org/2000/01/rdf-schema#comment | "Reversible acetylation of Tat is critical for its transactivation activity toward HIV-1 transcription. However, the enzymes involved in the acetylation/deacetylation cycles have not been fully characterized. In this study, by yeast two-hybrid assay, we have discovered the histone deacetylase HDAC6 to be a binding partner of Tat. Our data show that HDAC6 interacts with Tat in the cytoplasm in a microtubule-dependent manner. In addition, HDAC6 deacetylates Tat at Lys-28 and thereby suppresses Tat-mediated transactivation of the HIV-1 promoter. Inactivation of HDAC6 promotes the interaction of Tat with cyclin T1 and leads to an increase in Tat transactivation activity. These findings establish HDAC6 as a Tat deacetylase and support a model in which Lys-28 deacetylation decreases Tat transactivation activity through affecting the ability of Tat to form a ribonucleoprotein complex with cyclin T1 and the transactivation-responsive RNA."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.208884"xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Qiao W."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Huo L."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Aneja R."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/author | "Karna P."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/pages | "9280-9286"xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/title | "Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6."xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21220424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21220424 |
| http://purl.uniprot.org/citations/21220424 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21220424 |
| http://purl.uniprot.org/uniprot/#_B3KT76-mappedCitation-21220424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220424 |
| http://purl.uniprot.org/uniprot/#_B3KVK5-mappedCitation-21220424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220424 |
| http://purl.uniprot.org/uniprot/#_B3KNA1-mappedCitation-21220424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220424 |
| http://purl.uniprot.org/uniprot/#_B3KMC3-mappedCitation-21220424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220424 |
| http://purl.uniprot.org/uniprot/#_B3KY98-mappedCitation-21220424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220424 |