| http://purl.uniprot.org/citations/21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21220749 | http://www.w3.org/2000/01/rdf-schema#comment | "B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that interacts with herpesvirus entry mediator (HVEM), and this interaction regulates pathogenesis in various immunologic diseases. In graft-versus-host disease (GVHD), BTLA unexpectedly mediates positive effects on donor T-cell survival, whereas immunologic mechanisms of this function have yet to be explored. In this study, we elucidated a role of BTLA in GVHD by applying the newly established agonistic anti-BTLA monoclonal antibody that stimulates BTLA signal without antagonizing BTLA-HVEM interaction. Our results revealed that provision of BTLA signal inhibited donor antihost T-cell responses and ameliorated GVHD with a successful engraftment of donor hematopoietic cells. These effects were dependent on BTLA signal into donor T cells but neither donor non-T cells nor recipient cells. On the other hand, expression of BTLA mutant lacking an intracellular signaling domain restored impaired survival of BTLA-deficient T cells, suggesting that BTLA also serves as a ligand that delivers HVEM prosurvival signal in donor T cells. Collectively, current study elucidated dichotomous functions of BTLA in GVHD to serve as a costimulatory ligand of HVEM and to transmit inhibitory signal as a receptor."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-08-301325"xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Sakoda Y."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Park J.J."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Tamada K."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Kuramasu A."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Geng D."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/author | "Davila E."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/pages | "2506-2514"xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/title | "Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway."xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21220749 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21220749 |
| http://purl.uniprot.org/citations/21220749 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21220749 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1A0-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P889-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6M8-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7D5-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |
| http://purl.uniprot.org/uniprot/#_E9QNY6-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |
| http://purl.uniprot.org/uniprot/#_F6Y2U8-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |
| http://purl.uniprot.org/uniprot/#_Q32MV8-mappedCitation-21220749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21220749 |