| http://purl.uniprot.org/citations/21224844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21224844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21224844 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium signalling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca(2+). Cation channels of sperm proteins (CATSPERS1-4) form an alkalinization-activated Ca(2+)-selective channel required for the hyperactivated motility of spermatozoa and male fertility. Each of the CatSper1-4 genes encodes a subunit of a tetramer surrounding a Ca(2+)-selective pore, in analogy with other six-transmembrane ion channel α subunits. In addition to the pore-forming proteins, the sperm Ca(2+) channel contains auxiliary subunits, CATSPERβ and CATSPERγ. Here, we identify the Tmem146 gene product as a novel subunit, CATSPERδ, required for CATSPER channel function. We find that mice lacking the sperm tail-specific CATSPERδ are infertile and their spermatozoa lack both Ca(2+) current and hyperactivated motility. We show that CATSPERδ is an essential element of the CATSPER channel complex and propose that CATSPERδ is required for proper CATSPER channel assembly and/or transport."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms1153"xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms1153"xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Clapham D.E."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Clapham D.E."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Krapivinsky G."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Krapivinsky G."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Krapivinsky L."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Krapivinsky L."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Chung J.J."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Chung J.J."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Navarro B."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/author | "Navarro B."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/pages | "153"xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/pages | "153"xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/title | "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/title | "A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa."xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/21224844 | http://purl.uniprot.org/core/volume | "2"xsd:string |