| http://purl.uniprot.org/citations/21228929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21228929 | http://www.w3.org/2000/01/rdf-schema#comment | "The effect of exogenous Gal-1 on cellular response and adhesion molecule expression was investigated in a classical model of acute inflammation induced by zymosan. C57BL6 mice, treated or not with human recombinant (hr) Gal-1, received i.p. injection of zymosan and peritoneal exudate, blood and mesentery were processed for cellular, biochemical, light and electron microscopic analysis after 4 and 24 h. Zymosan peritonitis provoked the expected signs of inflammation at 4 h, including a significant increase in extravasated PMNs in the mesentery and peritoneal exudate, mirrored by blood neutrophilia. These changes subsided after 24 h. Ultrastructural immunocytochemical analysis of PMNs showed significant Gal-1 expression and co-localization with L-selectin and β2-integrin in the plasma membrane and cytoplasm. Pharmacological treatment with hrGal-1 at 4 h produced an inhibition of PMN migration, associated with diminished expression of adhesion molecules, particularly β2-integrin, and TNF-α and IL-1β release by peritoneal cells. At 24 h, Gal-1 induced an increase in mononuclear phagocytic cell recruitment. In conclusion, our data propose an important mechanism of anti-inflammatory action of Gal-1, initially by modulation of pro-inflammatory cytokine release and PMN migration through an imbalance between adhesion molecule expression and, later, by promoting monocyte-macrophage recruitment."xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/author | "Oliani S.M."xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/author | "Gil C.D."xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/author | "Gullo C.E."xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/name | "Int J Clin Exp Pathol"xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/pages | "74-84"xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/title | "Effect of exogenous galectin-1 on leukocyte migration: modulation of cytokine levels and adhesion molecules."xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/21228929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21228929 |
| http://purl.uniprot.org/citations/21228929 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21228929 |
| http://purl.uniprot.org/uniprot/#_P16045-mappedCitation-21228929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21228929 |
| http://purl.uniprot.org/uniprot/P16045 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21228929 |