Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21232147http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21232147http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Diabetic cardiomyopathy, characterized by myocardial structural and functional changes, is a specific cardiomyopathy develops in patients with diabetes mellitus. The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3β signalling pathway in mediating the protective effects of tanshinone IIA (TSN) on diabetic cardiomyopathy.

Methods and results

Streptozocin (STZ) induced diabetic rats (n = 60) were randomized to receive TSN, TSN plus HOE140 (a kinin B2 receptor antagonist), or saline. Healthy Sprague-Dawley (SD) rats (n = 20) were used as control. Left ventricular function, myocardial apoptosis, myocardial ultrastructure, Akt, GSK-3β and NF-κB phosphorylation, the expression of TNF-α, IL-6 and myeloperoxidase (MPO) were examined. Cardiac function was well preserved as evidenced by increased left ventricular ejection fraction (LVEF) and ± dp/dt (maximum speed of contraction/relaxation), along with decreased myocardial apoptotic death after TSN administration. TSN pretreatment alleviated mitochondria ultrastructure changes. TSN also enhanced Akt and GSK-3β phosphorylation and inhibited NF-κB phosphorylation, resulting in decreased TNF-α, IL-6 and MPO activities. Moreover, pretreatment with HOE140 abolished the beneficial effects of TSN: a decrease in LVEF and ± dp/dt, an inhibition of cardiomyocyte apoptosis, a destruction of cardiomyocyte mitochondria cristae, a reduction of Akt and GSK-3β phosphorylation, an enhancement of NF-κB phosphorylation and an increase of TNF-α, IL-6 and MPO production.

Conclusion

These data indicated that TSN is cardioprotective in the context of diabetic cardiomyopathy through kinin B2 receptor-Akt-GSK-3β dependent pathway."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.org/dc/terms/identifier"doi:10.1186/1475-2840-10-4"xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Li W."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Sun D."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Shen M."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Zhang Z."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Yuan Y."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Zhao L."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/author"Cao F."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/name"Cardiovasc Diabetol"xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/pages"4"xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/title"Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3beta dependent pathway in experimental diabetic cardiomyopathy."xsd:string
http://purl.uniprot.org/citations/21232147http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/21232147http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21232147
http://purl.uniprot.org/citations/21232147http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21232147
http://purl.uniprot.org/uniprot/#_A0A0H2UI29-mappedCitation-21232147http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21232147
http://purl.uniprot.org/uniprot/#_A6KBC4-mappedCitation-21232147http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21232147
http://purl.uniprot.org/uniprot/#_A6KBC5-mappedCitation-21232147http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21232147
http://purl.uniprot.org/uniprot/#_G3V942-mappedCitation-21232147http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21232147
http://purl.uniprot.org/uniprot/#_P47196-mappedCitation-21232147http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21232147
▶