| http://purl.uniprot.org/citations/21233845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21233845 | http://www.w3.org/2000/01/rdf-schema#comment | "Several microRNA (miRNA) loci are found within genomic regions frequently deleted in primary neuroblastoma, including miR-885-5p at 3p25.3. In this study, we demonstrate that miR-885-5p is downregulated on loss of 3p25.3 region in neuroblastoma. Experimentally enforced miR-885-5p expression in neuroblastoma cell lines inhibits proliferation triggering cell cycle arrest, senescence and/or apoptosis. miR-885-5p leads to the accumulation of p53 protein and activates the p53 pathway, resulting in upregulation of p53 targets. Enforced miR-885-5p expression consistently leads to downregulation of cyclin-dependent kinase (CDK2) and mini-chromosome maintenance protein (MCM5). Both genes are targeted by miR-885-5p via predicted binding sites within the 3'-untranslated regions (UTRs) of CDK2 and MCM5. Transcript profiling after miR-885-5p introduction in neuroblastoma cells reveals alterations in expression of multiple genes, including several p53 target genes and a number of factors involved in p53 pathway activity. Taken together, these data provide evidence that miR-885-5p has a tumor suppressive role in neuroblastoma interfering with cell cycle progression and cell survival."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2010.164"xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Fischer M."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Ehemann V."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Schwab M."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Brors B."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Sagulenko V."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Zapatka M."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Speleman F."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Westermann F."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Savelyeva L."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Kumps C."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Mestdagh P."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Vandesompele J."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Afanasyeva E.A."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/author | "Theissen J."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/pages | "974-984"xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/title | "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival."xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/21233845 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21233845 |
| http://purl.uniprot.org/citations/21233845 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21233845 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-21233845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21233845 |