| http://purl.uniprot.org/citations/21236258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21236258 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity-induced adipose tissue inflammation is characterized by increased macrophage infiltration and cytokine production, and is associated with metabolic disorders. LIGHT/TNFSF14, a member of the TNF superfamily, plays a role in the development of various inflammatory diseases. The purpose of this study was to examine the involvement of soluble LIGHT (sLIGHT) in obesity-induced adipose tissue inflammatory responses. LIGHT gene expression on macrophages/adipocytes was upregulated by treatment with obesity-related factors. sLIGHT displayed chemotactic activity for macrophages and T cells, and enhanced inflammatory cytokine release from macrophages, adipocytes, and adipose tissue-derived SVF cells. The sLIGHT-induced inflammatory responses were blunted by neutralizing anti-HVEM antibody or knockout of HVEM, a receptor for sLIGHT. These findings indicate that sLIGHT enhances adipose tissue inflammatory responses through its interaction with HVEM."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.01.011"xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/author | "Kim H.M."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/author | "Yu R."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/author | "Choi H.S."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/author | "Kawada T."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/author | "Jeong C.S."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/pages | "579-584"xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/title | "LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM."xsd:string |
| http://purl.uniprot.org/citations/21236258 | http://purl.uniprot.org/core/volume | "585"xsd:string |
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