| http://purl.uniprot.org/citations/21239581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21239581 | http://www.w3.org/2000/01/rdf-schema#comment | "Bacteria regulate the frequency and timing of DNA replication initiation by controlling the activity of the replication initiator protein DnaA. SirA is a recently discovered regulator of DnaA in Bacillus subtilis whose synthesis is turned on at the start of sporulation. Here, we demonstrate that SirA contacts DnaA at a patch of 3 residues located on the surface of domain I of the replication initiator protein, corresponding to the binding site used by two unrelated regulators of DnaA found in other bacteria. We show that the interaction of SirA with domain I inhibits the ability of DnaA to bind to the origin of replication. DnaA mutants containing amino acid substitutions of the 3 residues are functional in replication initiation but are immune to inhibition by SirA."xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.01390-10"xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/author | "Grossman A.D."xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/author | "Losick R."xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/author | "Rahn-Lee L."xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/author | "Merrikh H."xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/name | "J Bacteriol"xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/pages | "1302-1307"xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/title | "The sporulation protein SirA inhibits the binding of DnaA to the origin of replication by contacting a patch of clustered amino acids."xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/21239581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21239581 |
| http://purl.uniprot.org/citations/21239581 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21239581 |
| http://purl.uniprot.org/uniprot/#_P45707-mappedCitation-21239581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21239581 |
| http://purl.uniprot.org/uniprot/#_P05648-mappedCitation-21239581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21239581 |
| http://purl.uniprot.org/uniprot/P45707 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21239581 |
| http://purl.uniprot.org/uniprot/P05648 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21239581 |