| http://purl.uniprot.org/citations/21240187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21240187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21240187 | http://www.w3.org/2000/01/rdf-schema#comment | "Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKβ, a Cdc42 effector kinase that modulates cell protrusion and migration, at the leading edge of migrating cells. Structural studies reveal that the binding of a β hairpin from GRINL1A converts ZO-1 ZU5 into a complete ZU5-fold. A similar interaction mode is likely to occur between ZO-1 ZU5 and MRCKβ. The interaction between ZO-1 and MRCKβ requires the kinase to be primed by Cdc42 due to the closed conformation of the kinase. Formation of the ZO-1/MRCKβ complex enriches the kinase at the lamellae of migrating cells. Disruption of the ZO-1/MRCKβ complex inhibits MRCKβ-mediated cell migration. These results demonstrate that ZO-1, a classical scaffold protein with accepted roles in maintaining cell-cell adhesions in stable tissues, also has an active role in cell migration during processes such as tissue development and remodelling."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.353"xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.353"xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Xia J."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Xia J."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Wen W."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Wen W."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Feng W."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Feng W."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Huo L."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Huo L."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Kam C."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/author | "Kam C."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/pages | "665-678"xsd:string |
| http://purl.uniprot.org/citations/21240187 | http://purl.uniprot.org/core/pages | "665-678"xsd:string |