| http://purl.uniprot.org/citations/21241890 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21241890 | http://www.w3.org/2000/01/rdf-schema#comment | "PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here we show that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1, and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex. We find that nuclear exclusion but not phosphatase inactivation of PTEN impairs APC-CDH1. This nuclear function of PTEN provides a straightforward mechanistic explanation for the fail-safe cellular senescence response elicited by acute PTEN loss and the tumor-suppressive activity of catalytically inactive PTEN. Importantly, we demonstrate that PTEN mutant and PTEN null states are not synonymous as they are differentially sensitive to pharmacological inhibition of APC-CDH1 targets such as PLK1 and Aurora kinases. This finding identifies a strategy for cancer patient stratification and, thus, optimization of targeted therapies. PAPERCLIP:"xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2010.12.020"xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Carracedo A."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Song S.J."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Song M.S."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Salmena L."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/author | "Egia A."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/pages | "187-199"xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/title | "Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner."xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://purl.uniprot.org/core/volume | "144"xsd:string |
| http://purl.uniprot.org/citations/21241890 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21241890 |
| http://purl.uniprot.org/citations/21241890 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21241890 |
| http://purl.uniprot.org/uniprot/Q9UJX4#attribution-43959D6D4EF1B31DDFFC9438BF08A1C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/Q9UJX3#attribution-43959D6D4EF1B31DDFFC9438BF08A1C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/Q9UJX5#attribution-43959D6D4EF1B31DDFFC9438BF08A1C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/P30260#attribution-43959D6D4EF1B31DDFFC9438BF08A1C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/Q9R1K5#attribution-40C056C9E16BE1A8BDCE9AA0686273FB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/O08586#attribution-40C056C9E16BE1A8BDCE9AA0686273FB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/P60484#attribution-3C167078BBBF91CC736115AE2EBCD674 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |
| http://purl.uniprot.org/uniprot/P60484#attribution-43959D6D4EF1B31DDFFC9438BF08A1C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21241890 |