| http://purl.uniprot.org/citations/21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21242294 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary infection of mice with Aspergillus fumigatus induces concurrent T helper type 1 (Th1) and Th17 responses that depend on Toll-like receptor/MyD88 and Dectin-1, respectively. However, the mechanisms balancing Th1 and Th17 CD4 T cell populations during infection remain incompletely defined. In this study, we show that Dectin-1 deficiency disproportionally increases Th1 responses and decreases Th17 differentiation after A. fumigatus infection. Dectin-1 signaling in A. fumigatus-infected wild-type mice reduces IFN-γ and IL-12p40 expression in the lung, thereby decreasing T-bet expression in responding CD4 T cells and enhancing Th17 responses. Absence of IFN-γ or IL-12p35 in infected mice or T-bet in responding CD4 T cells enhances Th17 differentiation, independent of Dectin-1 expression, in A. fumigatus-infected mice. Transient deletion of monocyte-derived dendritic cells also reduces Th1 and boosts Th17 differentiation of A. fumigatus-specific CD4 T cells. Our findings indicate that Dectin-1-mediated signals alter CD4 T cell responses to fungal infection by decreasing the production of IL-12 and IFN-γ in innate cells, thereby decreasing T-bet expression in A. fumigatus-specific CD4 T cells and enabling Th17 differentiation."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20100906"xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Pamer E.G."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Saijo S."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Rivera A."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Collins N."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Hohl T.M."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Gallegos A."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Leiner I."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/author | "Coward J.W."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/pages | "369-381"xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/title | "Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://purl.uniprot.org/core/volume | "208"xsd:string |
| http://purl.uniprot.org/citations/21242294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21242294 |
| http://purl.uniprot.org/citations/21242294 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21242294 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21242294 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21242294 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21242294 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21242294 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21242294 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-21242294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21242294 |