| http://purl.uniprot.org/citations/21245038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21245038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21245038 | http://www.w3.org/2000/01/rdf-schema#comment | "The vertebrate 2-5A system is part of the innate immune system and central to cellular antiviral defense. Upon activation by viral double-stranded RNA, 5'-triphosphorylated, 2'-5'-linked oligoadenylate polyribonucleotides (2-5As) are synthesized by one of several 2'-5'-oligoadenylate synthetases. These unusual oligonucleotides activate RNase L, an unspecific endoribonuclease that mediates viral and cellular RNA breakdown. Subsequently, the 2-5As are removed by a 2'-phosphodiesterase (2'-PDE), an enzyme that apart from breaking 2'-5' bonds also degrades regular, 3'-5'-linked oligoadenylates. Interestingly, 2'-PDE shares both functionally and structurally characteristics with the CCR4-type exonuclease-endonuclease-phosphatase family of deadenylases. Here we show that 2'-PDE locates to the mitochondrial matrix of human cells, and comprise an active 3'-5' exoribonuclease exhibiting a preference for oligo-adenosine RNA like canonical cytoplasmic deadenylases. Furthermore, we document a marked negative association between 2'-PDE and mitochondrial mRNA levels following siRNA-directed knockdown and plasmid-mediated overexpression, respectively. The results indicate that 2'-PDE, apart from playing a role in the cellular immune system, may also function in mitochondrial RNA turnover."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkq1282"xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkq1282"xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Andersen K.R."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Andersen K.R."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Talbo G.H."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Talbo G.H."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Hoogenraad N."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Hoogenraad N."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Brodersen D.E."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Brodersen D.E."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Vestergaard A.L."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Vestergaard A.L."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Faou P."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Faou P."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Justesen J."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Justesen J."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Martensen P.M."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Martensen P.M."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Kjaer K.H."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Kjaer K.H."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Poulsen J.B."xsd:string |
| http://purl.uniprot.org/citations/21245038 | http://purl.uniprot.org/core/author | "Poulsen J.B."xsd:string |