| http://purl.uniprot.org/citations/21245352 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21245352 | http://www.w3.org/2000/01/rdf-schema#comment | "Internal ribosome entry site (IRES) RNAs are elements of viral or cellular mRNAs that bypass steps of canonical eukaryotic cap-dependent translation initiation. Understanding of the structural basis of IRES mechanisms is limited, partially due to a lack of high-resolution structures of IRES RNAs bound to their cellular targets. Prompted by the universal phylogenetic conservation of the ribosomal P site, we solved the crystal structures of proposed P site binding domains from two intergenic region IRES RNAs bound to bacterial 70S ribosomes. The structures show that these IRES domains nearly perfectly mimic a tRNA • mRNA interaction. However, there are clear differences in the global shape and position of this IRES domain in the intersubunit space compared to those of tRNA, supporting a mechanism for IRES action that invokes hybrid state mimicry to drive a noncanonical mode of translocation. These structures suggest how relatively small structured RNAs can manipulate complex biological machines."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1018582108"xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/author | "Noller H.F."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/author | "Kieft J.S."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/author | "Korostelev A."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/author | "Donohue J.P."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/author | "Costantino D.A."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/pages | "1839-1844"xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/title | "Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome."xsd:string |
| http://purl.uniprot.org/citations/21245352 | http://purl.uniprot.org/core/volume | "108"xsd:string |
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