| http://purl.uniprot.org/citations/21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21245386 | http://www.w3.org/2000/01/rdf-schema#comment | "AUF1 is an AU-rich element (ARE)-binding protein that recruits translation initiation factors, molecular chaperones, and mRNA degradation enzymes to the ARE for mRNA destruction. We recently found chaperone Hsp27 to be an AUF1-associated ARE-binding protein required for tumor necrosis factor alpha (TNF-α) mRNA degradation in monocytes. Hsp27 is a multifunctional protein that participates in ubiquitination of proteins for their degradation by proteasomes. A variety of extracellular stimuli promote Hsp27 phosphorylation on three serine residues--Ser(15), Ser(78), and Ser(82)-by a number of kinases, including the mitogen-activated protein (MAP) pathway kinases p38 and MK2. Activating either kinase stabilizes ARE mRNAs. Likewise, ectopic expression of phosphomimetic mutant forms of Hsp27 stabilizes reporter ARE mRNAs. Here, we continued to examine the contributions of Hsp27 to mRNA degradation. As AUF1 is ubiquitinated and degraded by proteasomes, we addressed the hypothesis that Hsp27 phosphorylation controls AUF1 levels to modulate ARE mRNA degradation. Indeed, selected phosphomimetic mutants of Hsp27 promote proteolysis of AUF1 in a proteasome-dependent fashion and render ARE mRNAs more stable. Our results suggest that the p38 MAP kinase (MAPK)-MK2-Hsp27 signaling axis may target AUF1 destruction by proteasomes, thereby promoting ARE mRNA stabilization."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00907-10"xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Hernandez K."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Krause C.D."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Pestka S."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Brewer G."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Jensen A.G."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Bradley J.J."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Gratacos F.M."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/author | "Knapinska A.M."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/pages | "1419-1431"xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/title | "Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation."xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21245386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21245386 |
| http://purl.uniprot.org/citations/21245386 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21245386 |
| http://purl.uniprot.org/uniprot/#_A0A8E9ZT92-mappedCitation-21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245386 |
| http://purl.uniprot.org/uniprot/#_A0A8E9ZUD7-mappedCitation-21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245386 |
| http://purl.uniprot.org/uniprot/#_B4DTC3-mappedCitation-21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245386 |
| http://purl.uniprot.org/uniprot/#_B4E0W4-mappedCitation-21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245386 |
| http://purl.uniprot.org/uniprot/#_B4DL87-mappedCitation-21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245386 |
| http://purl.uniprot.org/uniprot/#_C9J3N8-mappedCitation-21245386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245386 |