| http://purl.uniprot.org/citations/21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21245485 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous authors have suggested that tumor suppressor expression promotes aging while preventing cancer, but direct experimental support for this cancer-aging hypothesis has been elusive. Here, by using somatic, tissue-specific inactivation of the p16(INK4a) tumor suppressor in murine T- or B-lymphoid progenitors, we report that ablation of p16(INK4a) can either rescue aging or promote cancer in a lineage-specific manner. Deletion of p16(INK4a) in the T lineage ameliorated several aging phenotypes, including thymic involution, decreased production of naive T cells, reduction in homeostatic T-cell proliferation, and attenuation of antigen-specific immune responses. Increased T-cell neoplasia was not observed with somatic p16(INK4a) inactivation in T cells. In contrast, B lineage-specific ablation of p16(INK4a) was associated with a markedly increased incidence of systemic, high-grade B-cell neoplasms, which limited studies of the effects of somatic p16(INK4a) ablation on B-cell aging. Together, these data show that expression of p16(INK4a) can promote aging and prevent cancer in related lymphoid progeny of a common stem cell."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-09-304402"xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Johnson S.M."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Rogers A.B."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Krishnamurthy J."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Sharpless N.E."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/author | "Fedoriw Y."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/pages | "3257-3267"xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/title | "Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21245485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21245485 |
| http://purl.uniprot.org/citations/21245485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21245485 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_A7LP29-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_Q3U1A5-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_P25918-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_P51480-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_Q3TQG5-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_Q3TA95-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |
| http://purl.uniprot.org/uniprot/#_Q64364-mappedCitation-21245485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21245485 |