| http://purl.uniprot.org/citations/21247902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21247902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21247902 | http://www.w3.org/2000/01/rdf-schema#comment | "Considerable attention has recently been paid to the N-Myc downstream-regulated gene (NDRG) family because of its potential as a tumor suppressor in many human cancers. Primary amino acid sequence information suggests that the NDRG family proteins may belong to the α/β-hydrolase (ABH) superfamily; however, their functional role has not yet been determined. Here, we present the crystal structures of the human and mouse NDRG2 proteins determined at 2.0 and 1.7 Å resolution, respectively. Both NDRG2 proteins show remarkable structural similarity to the ABH superfamily, despite limited sequence similarity. Structural analysis suggests that NDRG2 is a nonenzymatic member of the ABH superfamily, because it lacks the catalytic signature residues and has an occluded substrate-binding site. Several conserved structural features suggest NDRG may be involved in molecular interactions. Mutagenesis data based on the structural analysis support a crucial role for helix α6 in the suppression of TCF/β-catenin signaling in the tumorigenesis of human colorectal cancer, via a molecular interaction."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.170803"xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.170803"xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Deacon A.M."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Deacon A.M."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Hwang J."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Hwang J."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Jaroszewski L."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Jaroszewski L."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Oh T.K."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Oh T.K."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim K.J."xsd:string |
| http://purl.uniprot.org/citations/21247902 | http://purl.uniprot.org/core/author | "Kim K.J."xsd:string |