| http://purl.uniprot.org/citations/21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21248258 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4 Th cells producing the proinflammatory cytokine IL-17 (Th17) have been implicated in a number of inflammatory arthritides including the spondyloarthritides. Th17 development is promoted by IL-23. Ankylosing spondylitis, the most common spondyloarthritis (SpA), is genetically associated with both HLA-B27 (B27) and IL-23R polymorphisms; however, the link remains unexplained. We have previously shown that B27 can form H chain dimers (termed B27(2)), which, unlike classical HLA-B27, bind the killer-cell Ig-like receptor KIR3DL2. In this article, we show that B27(2)-expressing APCs stimulate the survival, proliferation, and IL-17 production of KIR3DL2(+) CD4 T cells. KIR3DL2(+) CD4 T cells are expanded and enriched for IL-17 production in the blood and synovial fluid of patients with SpA. Despite KIR3DL2(+) cells comprising a mean of just 15% of CD4 T in the peripheral blood of SpA patients, this subset accounted for 70% of the observed increase in Th17 numbers in SpA patients compared with control subjects. TCR-stimulated peripheral blood KIR3DL2(+) CD4 T cell lines from SpA patients secreted 4-fold more IL-17 than KIR3DL2(+) lines from controls or KIR3DL2(-) CD4 T cells. Strikingly, KIR3DL2(+) CD4 T cells account for the majority of peripheral blood CD4 T cell IL-23R expression and produce more IL-17 in the presence of IL-23. Our findings link HLA-B27 with IL-17 production and suggest new therapeutic strategies in ankylosing spondylitis/SpA."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002653"xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Shaw J."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Ridley A."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Bowness P."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Kollnberger S."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "McMichael A."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Fleming M."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Chan A.T."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Wong-Baeza I."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/author | "Cummings F."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/pages | "2672-2680"xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/title | "Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis."xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21248258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21248258 |
| http://purl.uniprot.org/citations/21248258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21248258 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248258 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248258 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248258 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248258 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248258 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-21248258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248258 |