| http://purl.uniprot.org/citations/21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21248481 | http://www.w3.org/2000/01/rdf-schema#comment | "Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a genetic link between cell size, growth rate and lifespan. Mutations that increase cell size concomitantly increase growth rate and decrease lifespan. As a result, large cells grow, divide and age dramatically faster than small cells. Conversely, small cell mutants age slowly and are long-lived. Investigation of the mechanisms involved suggests that attainment of a maximal size modulates lifespan. Indeed, cumulative results revealed that life expectancy is size-dependent, and that the rate at which cells age is determined in large part by the amount of cell growth per generation."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.10.1.14455"xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Lane W."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Schneider B.L."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Hua H."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Wright J."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Dungrawala H."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Abraham L."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Manukyan A."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/author | "Mead H."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/pages | "144-155"xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/title | "Cell size and growth rate are major determinants of replicative lifespan."xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/21248481 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21248481 |
| http://purl.uniprot.org/citations/21248481 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21248481 |
| http://purl.uniprot.org/uniprot/#_P0C2H8-mappedCitation-21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248481 |
| http://purl.uniprot.org/uniprot/#_P0CX27-mappedCitation-21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248481 |
| http://purl.uniprot.org/uniprot/#_P0CX28-mappedCitation-21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248481 |
| http://purl.uniprot.org/uniprot/#_P0CX41-mappedCitation-21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248481 |
| http://purl.uniprot.org/uniprot/#_P22936-mappedCitation-21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248481 |
| http://purl.uniprot.org/uniprot/#_P13365-mappedCitation-21248481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21248481 |