| http://purl.uniprot.org/citations/21253969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21253969 | http://www.w3.org/2000/01/rdf-schema#comment | "This study elucidates the significance of Toll-like receptor 4 (TLR4), CD14, and nuclear factor (NF)-κB on the pathogenesis of ulcerative colitis (UC). Colonic biopsy specimens were collected from active UC and controls. The expression of TLR4, CD14, and NF-κBp 65 was analyzed by immunohistochemistry (IHC) and reverse-transcription polymerase chain reaction (RT-PCR). In UC, disease activity index (DAI) and pathological grade were classified according to the Powell-Tuck grade system and Truelove-Richards system, respectively. Fifty-six UC cases and 56 controls entered the investigation. IHC and RT-PCR revealed a significant increase of TLR4, CD14, and NF-κBp 65 antigen expression in colonic mucosa of UC compared with colonic mucosa of controls (p < .001). In UC, TLR4, CD14, and NF-κBp 65 expression were positively related to DAI (r = .873, p < .001; r = .576, p < .001; r = .747, p < .001 receptively). NF-κBp65 significantly correlated with TLR4 and CD14 (r = .669, p < .001; r = .576, p < .001, receptively). TLR4, CD14, and NF-κBp65 were positively related to pathological classification in UC (p < .01). Thus, TLR4, CD14, and NF-κBp65 were upregulated significantly in UC, to an extent that reflects the degree of inflammation and thereby might contribute to the occurrence and development of UC."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.org/dc/terms/identifier | "doi:10.1080/15321819.2010.538108"xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Zhao D.M."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Yu Z.H."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Liu H.F."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/author | "Hu F.A."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/name | "J Immunoassay Immunochem"xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/pages | "47-56"xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/title | "Expression of Toll-like receptor 4, CD14, and NF-kappaB in Chinese patients with ulcerative colitis."xsd:string |
| http://purl.uniprot.org/citations/21253969 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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