| http://purl.uniprot.org/citations/21255825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21255825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21255825 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphocytes by deaminating cytidines on template and nontemplate strands of transcribed DNA substrates. However, the mechanism of AID access to the template DNA strand, particularly when hybridized to a nascent RNA transcript, has been an enigma. We now implicate the RNA exosome, a cellular RNA-processing/degradation complex, in targeting AID to both DNA strands. In B lineage cells activated for CSR, the RNA exosome associates with AID, accumulates on IgH switch regions in an AID-dependent fashion, and is required for optimal CSR. Moreover, both the cellular RNA exosome complex and a recombinant RNA exosome core complex impart robust AID- and transcription-dependent DNA deamination of both strands of transcribed SHM substrates in vitro. Our findings reveal a role for noncoding RNA surveillance machinery in generating antibody diversity."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.01.001"xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.01.001"xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Lima C.D."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Lima C.D."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Deng H."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Deng H."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Gregory R.I."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Gregory R.I."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Pefanis E."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Pefanis E."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Basu U."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Basu U."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Myers D."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Myers D."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Januszyk K."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Januszyk K."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Meng F.L."xsd:string |
| http://purl.uniprot.org/citations/21255825 | http://purl.uniprot.org/core/author | "Meng F.L."xsd:string |