| http://purl.uniprot.org/citations/21257637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21257637 | http://www.w3.org/2000/01/rdf-schema#comment | "TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a multifunctional protein with roles in transcription, pre-messenger ribonucleic acid (mRNA) splicing, mRNA stability and transport. TDP-43 interacts with other heterogeneous nuclear ribonucleoproteins (hnRNPs), including hnRNP A2, via its C-terminus and several hnRNP family members are involved in the cellular stress response. This relationship led us to investigate the role of TDP-43 in cellular stress. Our results demonstrate that TDP-43 and hnRNP A2 are localized to stress granules (SGs), following oxidative stress, heat shock and exposure to thapsigargin. TDP-43 contributes to both the assembly and maintenance of SGs in response to oxidative stress and differentially regulates key SGs components, including TIA-1 and G3BP. The controlled aggregation of TIA-1 is disrupted in the absence of TDP-43 resulting in slowed SG formation. In addition, TDP-43 regulates the levels of G3BP mRNA, a SG nucleating factor. The disease-associated mutation TDP-43(R361S) is a loss-of-function mutation with regards to SG formation and confers alterations in levels of G3BP and TIA-1. In contrast, a second mutation TDP-43(D169G) does not impact this pathway. Thus, mutations in TDP-43 are mechanistically divergent. Finally, the cellular function of TDP-43 extends beyond splicing and places TDP-43 as a participant of the central cellular response to stress and an active player in RNA storage."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddr021"xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Rouleau G.A."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Camu W."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Vande Velde C."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Destroismaisons L."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Aulas A."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "McDonald K.K."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Pickles S."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/author | "Beleac E."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/pages | "1400-1410"xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/title | "TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1."xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/21257637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21257637 |
| http://purl.uniprot.org/citations/21257637 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21257637 |
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| http://purl.uniprot.org/uniprot/#_A0A0A0N0N3-mappedCitation-21257637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21257637 |
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