| http://purl.uniprot.org/citations/21262767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21262767 | http://www.w3.org/2000/01/rdf-schema#comment | "Vesicular transport along microtubules must be strictly regulated to sustain the unique structural and functional polarization of bone-resorbing osteoclasts. However, the molecular mechanisms bridging these vesicle-microtubule interactions remain largely obscure. Rab3D, a member of the Rab3 subfamily (Rab3A/B/C/D) of small exocytotic GTPases, represents a core component of the osteoclastic vesicle transport machinery. Here, we identify a new Rab3D-interacting partner, Tctex-1, a light chain of the cytoplasmic dynein microtubule motor complex, by a yeast two-hybrid screen. We demonstrate that Tctex-1 binds specifically to Rab3D in a GTP-dependent manner and co-occupies Rab3D-bearing vesicles in bone-resorbing osteoclasts. Furthermore, we provide evidence that Tctex-1 and Rab3D intimately associate with the dynein motor complex and microtubules in osteoclasts. Finally, targeted disruption of Tctex-1 by RNA interference significantly impairs bone resorption capacity and mislocalizes Rab3D vesicles in osteoclasts, attesting to the notion that components of the Rab3D-trafficking pathway contribute to the maintenance of osteoclastic resorptive function."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00834-10"xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Jahn R."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Cheng T.S."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Sung C.H."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Carrello A."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Ng P.Y."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Pavlos N.J."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Zheng M.H."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Qin A."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Feng H.T."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/author | "Ang E.S."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/pages | "1551-1564"xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/title | "Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption."xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21262767 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21262767 |
| http://purl.uniprot.org/citations/21262767 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21262767 |
| http://purl.uniprot.org/uniprot/P51807#attribution-73D019041C811E34679727299F55B812 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21262767 |
| http://purl.uniprot.org/uniprot/P63172#attribution-74BED2E91F435BF7D2031CC5079A2600 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21262767 |
| http://purl.uniprot.org/uniprot/O95716#attribution-74BED2E91F435BF7D2031CC5079A2600 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21262767 |
| http://purl.uniprot.org/uniprot/P35276#attribution-73D019041C811E34679727299F55B812 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21262767 |