| http://purl.uniprot.org/citations/21263072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21263072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21263072 | http://www.w3.org/2000/01/rdf-schema#comment | "Complexes of specific assembly factors and generic endoplasmic reticulum (ER) chaperones, collectively called the MHC class I peptide-loading complex (PLC), function in the folding and assembly of MHC class I molecules. The glycan-binding chaperone calreticulin (CRT) and partner oxidoreductase ERp57 are important in MHC class I assembly, but the sequence of assembly events and specific interactions involved remain incompletely understood. We show that the recruitments of CRT and ERp57 to the PLC are codependent and also dependent upon the ERp57 binding site and the glycan of the assembly factor tapasin. Furthermore, the ERp57 binding site and the glycan of tapasin enhance β(2)m and MHC class I heavy (H) chain recruitment to the PLC, with the ERp57 binding site having the dominant effect. In contrast, the conserved MHC class I H chain glycan played a minor role in CRT recruitment into the PLC, but impacted the recruitment of H chains into the PLC, and glycan-deficient H chains were impaired for tapasin-independent and tapasin-assisted assembly. The conserved MHC class I glycan and tapasin facilitated an early step in the assembly of H chain-β(2)m heterodimers, for which tapasin-ERp57 or tapasin-CRT complexes were not required. Together, these studies provide insights into how PLCs are constructed, demonstrate two distinct mechanisms by which PLCs can be stabilized, and suggest the presence of intermediate H chain-deficient PLCs."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002959"xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002959"xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Lybarger L."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Lybarger L."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Raghavan M."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Raghavan M."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Del Cid N."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Del Cid N."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Rizvi S.M."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/author | "Rizvi S.M."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/pages | "2309-2320"xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/pages | "2309-2320"xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/title | "Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/title | "Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules."xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21263072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21263072 |
| http://purl.uniprot.org/citations/21263072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21263072 |