| http://purl.uniprot.org/citations/21268071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21268071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21268071 | http://www.w3.org/2000/01/rdf-schema#comment | "SOD2 is a key mitochondrial antioxidant enzyme and its perturbation leads to oxidative cell death, which results in various disorders. In this study, we identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. The regulatory effect of USP36 on SOD2 was initially identified by 2-DE and MALDI-TOF/MS analyses. In addition, endogenous USP36 and SOD2 were shown to interact in an immunoprecipitation assay, which was verified using the yeast two-hybrid system. Furthermore, we demonstrated that SOD2 binds with ubiquitin molecules to form polyubiquitination chains and undergoes degradation through the ubiquitin-proteasomal pathway. Finally, USP36 was shown to be a specific deubiquitinating enzyme that reduces the ubiquitination level of SOD2 and was involved in SOD2 protein stability by extending its half-life."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22940"xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22940"xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Baek K.H."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Baek K.H."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Kim M.S."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Kim M.S."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Ramakrishna S."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Ramakrishna S."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Lim K.H."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/author | "Lim K.H."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/pages | "498-508"xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/pages | "498-508"xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/title | "Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/title | "Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36."xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/21268071 | http://purl.uniprot.org/core/volume | "112"xsd:string |