http://purl.uniprot.org/citations/21268678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21268678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21268678 | http://www.w3.org/2000/01/rdf-schema#comment | "Background Cataract is characterized by light-scattering protein aggregates. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s disease. The current study aimed to examine possible effects on cataract formation.Methods Patients with cataract (n = 493) and controls (n = 142) were analyzed for the UCHL1 p.S18Y polymorphism using dynamic allele-specific hybridization.Results Significant differences were observed in allele and genotype frequencies of the p.S18Y polymorphism between controls and cataract patients, where a positive UCHL1 allele A carrier status was associated with the cataract diagnosis (adjusted OR 1.7 [95% CI = 1.1-2.6] p = 0.02). No significant differences were seen in genotype distribution when stratifying for type of cataract. Nor did the mean age at cataract surgery differ between genotypes.Conclusion The current study does not support a protective role for the UCHL1 S18Y polymorphism in cataract development, but may instead suggest a disease-promoting effect."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.org/dc/terms/identifier | "doi:10.3109/13816810.2010.544360"xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.org/dc/terms/identifier | "doi:10.3109/13816810.2010.544360"xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Sjolander A."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Sjolander A."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Blennow K."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Blennow K."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Zetterberg H."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Zetterberg H."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Rudolph T."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Rudolph T."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Palmer M.S."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Palmer M.S."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Juronen E."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Juronen E."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Tasa G."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Tasa G."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Andreasen N."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Andreasen N."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Minthon L."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Minthon L."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Wallin A."xsd:string |
http://purl.uniprot.org/citations/21268678 | http://purl.uniprot.org/core/author | "Wallin A."xsd:string |