| http://purl.uniprot.org/citations/21270162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21270162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21270162 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor κB (NF-κB) transcription factors are involved in controlling numerous cellular processes, including inflammation, innate and adaptive immunity, and cell survival. Here we show that the immunosuppressive measles virus (MV; Morbillivirus genus, Paramyxoviridae) has evolved multiple functions to interfere with canonical NF-κB signaling in epithelial cells. The MV P, V, and C proteins, also involved in preventing host cell interferon responses, were found to individually suppress NF-κB-dependent reporter gene expression in response to activation of the tumor necrosis factor (TNF) receptor, RIG-I-like receptors, or Toll-like receptors. NF-κB activity was most efficiently suppressed in the presence of V, while expression of P or C resulted in moderate inhibition. As indicated by reporter gene assays involving overexpression of the IκB kinase (IKK) complex, which phosphorylates the inhibitor of κB to liberate NF-κB, V protein targets a downstream step in the signaling cascade. Coimmunoprecipitation experiments revealed that V specifically binds to the Rel homology domain of the NF-κB subunit p65 but not of p50. Notably, the short C-terminal domain of the V protein, which is also involved in binding STAT2, IRF7, and MDA5, was sufficient for the interaction and for preventing reporter gene activity. As observed by confocal microscopy, the presence of V abolished nuclear translocation of p65 upon TNF-α stimulation. Thus, MV V appears to prevent NF-κB-dependent gene expression by retaining p65 in the cytoplasm. These findings reveal NF-κB as a key target of MV and stress the importance of the V protein as the major viral immune-modulatory factor."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02342-10"xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02342-10"xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/author | "Conzelmann K.K."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/author | "Conzelmann K.K."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/author | "Pfaller C.K."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/author | "Pfaller C.K."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/author | "Schuhmann K.M."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/author | "Schuhmann K.M."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/pages | "3162-3171"xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/pages | "3162-3171"xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/title | "The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/title | "The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity."xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/21270162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21270162 |
| http://purl.uniprot.org/citations/21270162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21270162 |
| http://purl.uniprot.org/citations/21270162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21270162 |
| http://purl.uniprot.org/citations/21270162 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21270162 |