| http://purl.uniprot.org/citations/21270396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21270396 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin D and vitamin D receptor (VDR) deficiency results in severe symptoms of experimental inflammatory bowel disease in several different models. The intraepithelial lymphocytes of the small intestine contain large numbers of CD8αα(+) T cells that have been shown to suppress the immune response to Ags found there. In this study, we determined the role of the VDR in the development of CD8αα(+) T cells. There are fewer total numbers of TCRαβ(+) T cells in the gut of VDR knockout (KO) mice, and that reduction was largely in the CD8αα(+) TCRαβ(+) cells. Conversely TCRγδ(+) T cells were normal in the VDR KO mice. The thymic precursors of CD8αα(+) TCRαβ(+) cells (triple-positive for CD4, CD8αα, and CD8αβ) were reduced and less mature in VDR KO mice. In addition, VDR KO mice had a higher frequency of the CD8αα(+) TCRαβ(+) precursors (double-negative [DN] TCRαβ(+) T cells) in the gut. The proliferation rates of the DN TCRαβ(+) gut T cells were less in the VDR KO compared with those in wild type. Low proliferation of DN TCRαβ(+) T cells was a result of the very low expression of the IL-15R in this population of cells in the absence of the VDR. Bone marrow transplantation showed that the defect in VDR KO CD8αα(+) TCRαβ(+) cells was cell intrinsic. Decreased maturation and proliferation of CD8αα(+) TCRαβ(+) cells in VDR KO mice results in fewer functional CD8αα(+) TCRαβ(+) T cells, which likely explains the increased inflammation in the gastrointestinal tract of VDR KO and vitamin D-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1003444"xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/author | "Bruce D."xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/author | "Cantorna M.T."xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/pages | "2819-2825"xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/title | "Intrinsic requirement for the vitamin D receptor in the development of CD8alphaalpha-expressing T cells."xsd:string |
| http://purl.uniprot.org/citations/21270396 | http://purl.uniprot.org/core/volume | "186"xsd:string |
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