| http://purl.uniprot.org/citations/21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21273415 | http://www.w3.org/2000/01/rdf-schema#comment | "The modification of the neural cell adhesion molecule (NCAM) with polysialic acid (polySia) is tightly linked to neural development. Genetic ablation of the polySia-synthesizing enzymes ST8SiaII and ST8SiaIV generates polySia-negative but NCAM-positive (II(-/-)IV(-/-)) mice characterized by severe defects of major brain axon tracts, including internal capsule hypoplasia. Here, we demonstrate that misguidance of thalamocortical fibers and deficiencies of corticothalamic connections contribute to internal capsule defects in II(-/-)IV(-/-) mice. Thalamocortical fibers cross the primordium of the reticular thalamic nucleus (Rt) at embryonic day 14.5, before they fail to turn into the ventral telencephalon, thus deviating from their normal trajectory without passing through the internal capsule. At postnatal day 1, a reduction and massive disorganization of fibers traversing the Rt was observed, whereas terminal deoxynucleotidyl transferase dUTP nick end labeling and cleaved caspase-3 staining indicated abundant apoptotic cell death of Rt neurons at postnatal day 5. Furthermore, during postnatal development, the number of Rt neurons was drastically reduced in 4-week-old II(-/-)IV(-/-) mice, but not in the NCAM-deficient N(-/-) or II(-/-)IV(-/-)N(-/-) triple knock-out animals displaying no internal capsule defects. Thus, degeneration of the Rt in II(-/-)IV(-/-) mice may be a consequence of malformation of thalamocortical and corticothalamic fibers providing major excitatory input into the Rt. Indeed, apoptotic death of Rt neurons could be induced by lesioning corticothalamic fibers on whole-brain slice cultures. We therefore propose that anterograde transneuronal degeneration of the Rt in polysialylation-deficient, NCAM-positive mice is caused by defective afferent innervation attributable to thalamocortical pathfinding defects."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5609-10.2011"xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/author | "Burkhardt H."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/author | "Schiff M."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/author | "Weinhold B."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/author | "Hildebrandt H."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/author | "Rockle I."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/pages | "1302-1312"xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/title | "Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21273415 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21273415 |
| http://purl.uniprot.org/citations/21273415 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX5-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A087WPS6-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A087WQQ9-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWU2-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWW5-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY47-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY91-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A087WPI9-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |
| http://purl.uniprot.org/uniprot/#_A0A087WRA0-mappedCitation-21273415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21273415 |