| http://purl.uniprot.org/citations/21276005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21276005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21276005 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed death-1 (PD-1) is a surface receptor critical for the regulation of T cell function during immunity and tolerance. PD-1 interactions with its ligands PD-L1 and PD-L2 inhibit T cell effector functions in an antigen-specific manner. This paper examines the role of PD-1 in limiting autoreactivity and establishing self-tolerance and discusses the hypothesis that PD-1 ligand (PD-L) expression both spatially and temporally dictates the fate of self-reactive T cells during the breakdown of peripheral tolerance and development of autoimmunity. We focus our discussion on the role of PD-1/PD-L interactions during peripheral tolerance, the differential role for PD-L1 and PD-L2 in response to environmental or self-antigens, and the impact of PD-1 signaling on dynamic T cell motility and the T cell receptor (TCR) stop signal. Finally, we discuss the potential to selectively target the PD-1 pathway therapeutically to alter T cell function during autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1749-6632.2010.05919.x"xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1749-6632.2010.05919.x"xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/author | "Fife B.T."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/author | "Fife B.T."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/author | "Pauken K.E."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/author | "Pauken K.E."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/name | "Ann. N. Y. Acad. Sci."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/name | "Ann. N. Y. Acad. Sci."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/pages | "45-59"xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/pages | "45-59"xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/title | "The role of the PD-1 pathway in autoimmunity and peripheral tolerance."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/title | "The role of the PD-1 pathway in autoimmunity and peripheral tolerance."xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/volume | "1217"xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://purl.uniprot.org/core/volume | "1217"xsd:string |
| http://purl.uniprot.org/citations/21276005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21276005 |
| http://purl.uniprot.org/citations/21276005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21276005 |
| http://purl.uniprot.org/citations/21276005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21276005 |
| http://purl.uniprot.org/citations/21276005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21276005 |
| http://purl.uniprot.org/uniprot/Q15116 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/21276005 |
| http://purl.uniprot.org/uniprot/Q15116#attribution-63B477D8041AD3E0CE991A067E26A108 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21276005 |