| http://purl.uniprot.org/citations/21277013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21277013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21277013 | http://www.w3.org/2000/01/rdf-schema#comment | "The centriole, and the related basal body, is an ancient organelle characterized by a universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes. The mechanisms directing centriole formation are incompletely understood and represent a fundamental open question in biology. Here, we demonstrate that the centriolar protein SAS-6 forms rod-shaped homodimers that interact through their N-terminal domains to form oligomers. We establish that such oligomerization is essential for centriole formation in C. elegans and human cells. We further generate a structural model of the related protein Bld12p from C. reinhardtii, in which nine homodimers assemble into a ring from which nine coiled-coil rods radiate outward. Moreover, we demonstrate that recombinant Bld12p self-assembles into structures akin to the central hub of the cartwheel, which serves as a scaffold for centriole formation. Overall, our findings establish a structural basis for the universal 9-fold symmetry of centrioles."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.01.008"xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.01.008"xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Steinmetz M.O."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Steinmetz M.O."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Vakonakis I."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Vakonakis I."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Hilbert M."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Hilbert M."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Gonczy P."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Gonczy P."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Olieric N."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Olieric N."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Olieric V."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Olieric V."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Fluckiger I."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Fluckiger I."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Kitagawa D."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Kitagawa D."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Keller D."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Keller D."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Erat M.C."xsd:string |
| http://purl.uniprot.org/citations/21277013 | http://purl.uniprot.org/core/author | "Erat M.C."xsd:string |