| http://purl.uniprot.org/citations/21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21278706 | http://www.w3.org/2000/01/rdf-schema#comment | "Large alterations in transcription accompany neurodegeneration in polyglutamine (polyQ) diseases. These pathologies manifest both general polyQ toxicity and mutant protein-specific effects. In this study, we report that the fat tumour suppressor gene mediates neurodegeneration induced by the polyQ protein Atrophin. We have monitored early transcriptional alterations in a Drosophila model of Dentatorubral-pallidoluysian Atrophy and found that polyQ Atrophins downregulate fat. Fat protects from neurodegeneration and Atrophin toxicity through the Hippo kinase cascade. Fat/Hippo signalling does not provoke neurodegeneration by stimulating overgrowth; rather, it alters the autophagic flux in photoreceptor neurons, thereby affecting cell homeostasis. Our data thus provide a crucial insight into the specific mechanism of a polyQ disease and reveal an unexpected neuroprotective role of the Fat/Hippo pathway."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.1"xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Charroux B."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Blanc E."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Royet J."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Fanto M."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Occhi S."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Calamita P."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Napoletano F."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/author | "Volpi V."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/pages | "945-958"xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/title | "Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat."xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21278706 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21278706 |
| http://purl.uniprot.org/citations/21278706 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD4-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFV9-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFW0-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEP0-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEU3-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF22-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LEY0-mappedCitation-21278706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278706 |