| http://purl.uniprot.org/citations/21278753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21278753 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock cognate protein-70 (Hsc70) supports remodeling of protein complexes, such as disassembly of clathrin coats on endocytic coated vesicles. To understand how a simple ATP-driven molecular clamp catalyzes a large-scale disassembly reaction, we have used single-particle fluorescence imaging to track the dynamics of Hsc70 and its clathrin substrate in real time. Hsc70 accumulates to a critical level, determined by kinetic modeling to be one Hsc70 for every two functional attachment sites; rapid, all-or-none uncoating then ensues. We propose that Hsc70 traps conformational distortions, seen previously by cryo-EM, in the vicinity of each occupied site and that accumulation of local strains destabilizes the clathrin lattice. Capture of conformational fluctuations may be a general mechanism for chaperone-driven disassembly of protein complexes."xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1985"xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/author | "Harrison S.C."xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/author | "Kirchhausen T."xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/author | "Aguet F."xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/author | "Bocking T."xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/pages | "295-301"xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/title | "Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating."xsd:string |
| http://purl.uniprot.org/citations/21278753 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P01133-mappedCitation-21278753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278753 |
| http://purl.uniprot.org/uniprot/#_P01135-mappedCitation-21278753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278753 |
| http://purl.uniprot.org/uniprot/#_P21579-mappedCitation-21278753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278753 |