| http://purl.uniprot.org/citations/21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21278788 | http://www.w3.org/2000/01/rdf-schema#comment | "Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation. TCTP has been found to interact directly with the third cytoplasmic domain of the α subunit of Na,K-ATPase, but whether this interaction has a role in tumorigenesis is unclear. In this study, we examined TCTP-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. We found that TCTP (a) induces Src release from Na,K-ATPase α subunit and Src activation; (b) phosphorylates tyrosine residues 845, 992, 1086, 1148 and 1173 on anti-epidermal growth factor receptor (EGFR); (c) activates PI3K (phosphatidylinositol 3-kinase )-AKT, Ras-Raf-MEK-ERK1/2, Rac-PAK1/2, MKK3/6-p38 and phospholipase C (PLC)-γ pathways; (d) enhances NADPH oxidase-dependent reactive oxygen species (ROS) generation; (e) stimulates cytoskeletal remodeling and cell motility and (f) upregulates matrix metalloproteinase (MMP) 3 and 13. These findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.604"xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/author | "Kim H.Y."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/author | "Sohn K."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/author | "Kim M.'"xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/pages | "2264-2274"xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/title | "Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src."xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21278788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21278788 |
| http://purl.uniprot.org/citations/21278788 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21278788 |
| http://purl.uniprot.org/uniprot/#_Q14925-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_P00533-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_Q13480-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_P13693-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_P05023-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_P12931-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_P29353-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_P62993-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |
| http://purl.uniprot.org/uniprot/#_Q71UK5-mappedCitation-21278788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21278788 |