| http://purl.uniprot.org/citations/21281623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21281623 | http://www.w3.org/2000/01/rdf-schema#comment | "Urinary tract morphogenesis requires subdivision of the ureteric bud (UB) into the intra-renal collecting system and the extra-renal ureter, by responding to signals in its surrounding mesenchyme. BMP4 is a mesenchymal regulator promoting ureter development, while GREM1 is necessary to negatively regulate BMP4 activity to induce UB branching. However, the mechanisms that regulate the GREM1-BMP4 signaling are unknown. Previous studies have shown that Six1-deficient mice lack kidneys, but form ureters. Here, we show that the tip cells of Six1(-/-) UB fail to form an ampulla for branching. Instead, the UB elongates within Tbx18- and Bmp4-expressing mesenchyme. We find that the expression of Grem1 in the metanephric mesenchyme (MM) is Six1-dependent. Treatment of Six1(-/-) kidney rudiments with GREM1 protein restores ampulla formation and branching morphogenesis. Furthermore, we demonstrate that genetic reduction of BMP4 levels in Six1(-/-) (Six1(-/-); Bmp4(+/-)) embryos restores urinary tract morphogenesis and kidney formation. This study uncovers an essential function for Six1 in the MM as an upstream regulator of Grem1 in initiating branching morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2011.01.027"xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/author | "Nie X."xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/author | "Xu P.X."xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/author | "El-Hashash A."xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/pages | "141-151"xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/title | "Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/21281623 | http://purl.uniprot.org/core/volume | "352"xsd:string |
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