| http://purl.uniprot.org/citations/21281624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21281624 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2011.01.026"xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Ilovich O."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Stahlberg A."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Semb H."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Ahlgren U."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Dor Y."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Edsbagge J."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Magenheim J."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Johansson J.K."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Mishani E."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Sand F.W."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Hornblad A."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/author | "Loren C."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/pages | "267-277"xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/title | "Growth-limiting role of endothelial cells in endoderm development."xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://purl.uniprot.org/core/volume | "352"xsd:string |
| http://purl.uniprot.org/citations/21281624 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21281624 |
| http://purl.uniprot.org/citations/21281624 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21281624 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0H1-mappedCitation-21281624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21281624 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST05-mappedCitation-21281624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21281624 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-21281624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21281624 |