| http://purl.uniprot.org/citations/21282510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21282510 | http://www.w3.org/2000/01/rdf-schema#comment | "How the naive T cell repertoire arises and forms the memory repertoire is still poorly understood. This relationship was analyzed by taking advantage of the focused TCR usage in HLA-A2-restricted CD8 memory T cell responses to influenza M1(58-66). We analyzed rearranged BV19 genes from CD8 single-positive thymocytes, a surrogate for the naive repertoire, from 10 HLA-A2 individuals. CDR3 amino acid sequences associated with response to influenza were observed at higher frequencies than expected by chance, an indicator of preselection. We propose that a rearrangement mechanism involving long P-nucleotide addition from the J2.7 region explains part of this increase. Special rearrangement mechanisms can result in identical T cells in different individuals, referred to as public responses. Indeed, the rearrangements utilizing long P nucleotide additions were commonly observed in the response to the M1(58-66) epitope in 30 HLA-A2 middle-aged adults. Thus, in addition to negative and positive selection, special rearrangement mechanisms may influence the composition of the naive repertoire, resulting in more robust responses to a pathogen in some individuals."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002764"xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Ferrante A."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Gorski J."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Reed E."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Zacharias G."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Bosenko D."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Yassai M."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Demos W."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/author | "Unruh M."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/pages | "2970-2977"xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/title | "Naive T cell repertoire skewing in HLA-A2 individuals by a specialized rearrangement mechanism results in public memory clonotypes."xsd:string |
| http://purl.uniprot.org/citations/21282510 | http://purl.uniprot.org/core/volume | "186"xsd:string |
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