| http://purl.uniprot.org/citations/21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21285397 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian embryo relies on maternal circulating retinoids (vitamin A derivatives) for development. β-Carotene is the major human dietary provitamin A. β-Carotene-15,15'-oxygenase (CMOI) has been proposed as the main enzyme generating retinoid from β-carotene in vivo. CMOI is expressed in embryonic tissues, suggesting that β-carotene provides retinoids locally during development. We performed loss of CMOI function studies in mice lacking retinol-binding protein (RBP), an established model of embryonic vitamin A deficiency (VAD). We show that, unexpectedly, lack of CMOI in the developing tissues further exacerbates the severity of VAD and thus the embryonic malformations of RBP(-/-) mice. Since β-carotene was not present in any of the mouse diets, we unveiled a novel action of CMOI independent from its β-carotene cleavage activity. We also show for the first time that CMOI exerts an additional function on retinoid metabolism by influencing retinyl ester formation via modulation of lecithin:retinol acyltransferase (LRAT) activity, at least in developing tissues. Finally, we demonstrate unequivocally that β-carotene can serve as an alternative vitamin A source for the in situ synthesis of retinoids in developing tissues by the action of CMOI."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.10-175448"xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Chung S."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Kim Y.K."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Blaner W.S."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Wyss A."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Quadro L."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/author | "Wassef L."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/pages | "1641-1652"xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/title | "beta-Carotene and its cleavage enzyme beta-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues."xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21285397 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21285397 |
| http://purl.uniprot.org/citations/21285397 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21285397 |
| http://purl.uniprot.org/uniprot/#_A0A494B9P3-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_A0A494B9T2-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_B2RUR5-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_E9Q321-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_H7BWY6-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_Q00724-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_Q05AC0-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |
| http://purl.uniprot.org/uniprot/#_Q58EU7-mappedCitation-21285397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21285397 |