| http://purl.uniprot.org/citations/21289301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21289301 | http://www.w3.org/2000/01/rdf-schema#comment | "Autoimmune encephalomyelitis is a disease of the CNS that can develop when an initial peripheral inflammatory stimulus is followed by infiltration and reactivation of T lymphocytes in the CNS. We report a crucial role for coronin 1, which is essential for maintenance of the naive T cell pool, for the development of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. In the absence of coronin 1, immunization with myelin oligoglycoprotein (MOG(35-55)) peptide largely failed to induce EAE symptoms, despite normal mobilization of leukocyte subsets in the blood, as well as effector cytokine expression comparable with wild-type T cells on polyclonal stimulation. Susceptibility of coronin 1-deficient mice to EAE induction was restored by transfer of wild-type CD4(+) T cells, suggesting that the observed resistance of coronin 1-deficient mice to EAE development is T cell intrinsic. Importantly, although coronin 1-deficient regulatory T cells (Tregs) showed a suppressor activity comparable with wild-type Tregs, Treg depletion failed to restore EAE development in coronin 1-deficient animals. These results suggest a hitherto unrecognized role of naive T cells in the development of autoimmune encephalomyelitis and reveal coronin 1 as a crucial modulator of EAE induction."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1003491"xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/author | "Pieters J."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/author | "Siegmund K."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/author | "Schaeren-Wiemers N."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/author | "Kunz G."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/author | "Rolink T."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/author | "Zeis T."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/pages | "3452-3461"xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/title | "Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis."xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21289301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21289301 |
| http://purl.uniprot.org/citations/21289301 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21289301 |
| http://purl.uniprot.org/uniprot/#_D3YW57-mappedCitation-21289301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21289301 |
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| http://purl.uniprot.org/uniprot/#_Q3U232-mappedCitation-21289301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21289301 |
| http://purl.uniprot.org/uniprot/#_Q3U9K3-mappedCitation-21289301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21289301 |
| http://purl.uniprot.org/uniprot/#_O89053-mappedCitation-21289301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21289301 |
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