| http://purl.uniprot.org/citations/21289314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21289314 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanism by which apolipoprotein E (apoE) suppresses inflammatory cytokine and NO production is unknown. Using an affinity purification approach, we found that peptide mimetics of apoE, derived from its receptor binding domain residues 130-150, bound to the SET protein, which is a potent physiological inhibitor of protein phosphatase 2A (PP2A). Both holo-apoE protein and apoE-mimetic peptides bound to the C-terminal region of SET, which is then associated with an increase in PP2A-mediated phosphatase activity. As physiological substrates for PP2A, the LPS-induced phosphorylation status of signaling MAPK and Akt kinase is reduced following treatment with apoE-mimetic peptides. On the basis of our previous report, in which apoE-mimetic peptides reduced I-κB kinase and NF-κB activation, we also demonstrate a mechanism for reduced production of inducible NO synthase protein and its NO product. These data provide evidence for a novel molecular mechanism by which apoE and apoE-mimetic peptides antagonize SET, thereby enhancing endogenous PP2A phosphatase activity, which reduces levels of phosphorylated kinases, signaling, and inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002847"xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Van Kanegan M.J."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Ohkubo N."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Christensen D.J."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Vitek M.P."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Neil J."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Colton C.A."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/author | "Oddo J."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/pages | "2535-2542"xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/title | "Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A."xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21289314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21289314 |
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