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http://purl.uniprot.org/citations/21292197http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21292197http://www.w3.org/2000/01/rdf-schema#comment"

Background

Peritonitis is the most serious complication of peritoneal dialysis (PD). We previously showed that high levels of interleukin (IL)-12 and IL-18 in PD effluents (PDE) during the early phase of peritonitis correlated with a predominant Type 1 immune response and a favorable outcome in PD-related peritonitis. To further clarify the longitudinal changes of peritoneal immunity during PD-related peritonitis, we examined the kinetic production of IL-17 in PDE during peritonitis. The correlation between the IL-17 expression pattern and peritonitis outcome was analyzed.

Methods

The levels of IL-17 were measured in PDE during various phases of peritonitis in 38 patients undergoing PD. The patients were divided into two groups, according to whether they had a rapid versus a delayed response to antibiotic treatment.

Results

The kinetic expression of IL-17, as measured by enzyme-linked immunosorbent assay, differed between the two groups. In the rapid response group, high level of IL-17 was detected in PDE initially and progressively decreased during treatment. In the delayed response group, IL-17 levels in PDE were persistently low throughout the whole course of treatment. In the early phase of peritonitis, the IL-17 levels in PDE were significantly higher in the rapid response group (p<0.05).

Conclusion

These data suggested that local IL-17 production is part of a protective early immune response to PD-related peritonitis. High levels of IL-17 in PDE during the early phase of peritonitis correlated with a favorable outcome. Manipulation of IL-17 cytokine expression in patients with peritonitis may modulate peritoneal immune response and affect peritonitis outcome."xsd:string
http://purl.uniprot.org/citations/21292197http://purl.org/dc/terms/identifier"doi:10.1016/j.jcma.2011.01.002"xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/author"Lin C.Y."xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/author"Wang H.H."xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/author"Lee T.Y."xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/name"J Chin Med Assoc"xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/pages"11-15"xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/title"Kinetics and involvement of interleukin-17 in the outcome of peritonitis in nondiabetic patients undergoing peritoneal dialysis."xsd:string
http://purl.uniprot.org/citations/21292197http://purl.uniprot.org/core/volume"74"xsd:string
http://purl.uniprot.org/citations/21292197http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21292197
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