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| http://purl.uniprot.org/citations/21297578 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune signalling pathways need to be tightly regulated as overactivation of these pathways can result in chronic inflammatory diseases and cancer. NF-κB signalling and associated innate immune pathways are crucial in the first line of defense against infection in all animals. In a genome-wide RNAi screen for modulators of Drosophila immune deficiency (IMD)/NF-κB signalling, we identified components of the Ras/MAPK pathway as essential for suppression of IMD pathway activity, even in the absence of an immune challenge. Downregulation of Ras/MAPK activity mimics the induction of innate immune responses by microbial patterns. Conversely, ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-κB signalling. Mechanistically, we show that the Ras/MAPK pathway acts by inducing transcription of the IMD pathway inhibitor Pirk/Rudra/PIMS. Finally, in vivo experiments demonstrate a requirement for Ras/MAPK signalling in restricting innate immune responses in haemocytes, fat body and adult intestinal stem cells. Our observations provide an example of a pathway that promotes cell proliferation and has simultaneously been utilized to limit the immune response."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.4"xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/author | "Boutros M."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/author | "Buechling T."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/author | "Spirohn K."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/author | "Gesellchen V."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/author | "Ragab A."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/author | "Boettcher A.L."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/pages | "1123-1136"xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/title | "Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells."xsd:string |
| http://purl.uniprot.org/citations/21297578 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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