| http://purl.uniprot.org/citations/21299499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21299499 | http://www.w3.org/2000/01/rdf-schema#comment | "The IQGAP [IQ-motif-containing GAP (GTPase-activating protein)] family members are eukaryotic proteins that act at the interface between cellular signalling and the cytoskeleton. As such they collect numerous inputs from a variety of signalling pathways. A key binding partner is the calcium-sensing protein CaM (calmodulin). This protein binds mainly through a series of IQ-motifs which are located towards the middle of the primary sequence of the IQGAPs. In some IQGAPs, these motifs also provide binding sites for CaM-like proteins such as myosin essential light chain and S100B. Using synthetic peptides and native gel electrophoresis, the binding properties of the IQ-motifs from human IQGAP2 and IQGAP3 have been mapped. The second and third IQ-motifs in IQGAP2 and all four of the IQ-motifs of IQGAP3 interacted with CaM in the presence of calcium ions. However, there were differences in the type of interaction: while some IQ-motifs were able to form complexes with CaM which were stable under the conditions of the experiment, others formed more transient interactions. The first IQ-motifs from IQGAP2 and IQGAP3 formed transient interactions with CaM in the absence of calcium and the first motif from IQGAP3 formed a transient interaction with the myosin essential light chain Mlc1sa. None of these IQ-motifs interacted with S100B. Molecular modelling suggested that all of the IQ-motifs, except the first one from IQGAP2 formed α-helices in solution. These results extend our knowledge of the selectivity of IQ-motifs for CaM and related proteins."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.org/dc/terms/identifier | "doi:10.1042/bsr20100123"xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/author | "Timson D.J."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/author | "Hamilton E."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/author | "Greer B."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/author | "Pathmanathan S."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/author | "Harriott P."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/author | "Atcheson E."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/name | "Biosci Rep"xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/pages | "371-379"xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/title | "IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain."xsd:string |
| http://purl.uniprot.org/citations/21299499 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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