| http://purl.uniprot.org/citations/21299526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21299526 | http://www.w3.org/2000/01/rdf-schema#comment | "The human leukocyte antigen G (HLA-G) molecule, a non-classical major histocompatibility complex class I antigen, exhibits highly limited tissue distribution and gene variation. Recent studies indicate strong immunoinhibitory properties in tumor cells that may favor their escape from anti-tumor immune responses. However, the role of HLA-G in cervical premalignant and malignant lesions has not been defined clearly. In our study, HLA-G expression was studied in cervical tissue from 119 patients with lesions and 22 normal cervical tissue specimens by immunohistochemistry. HLA-G was expressed in 45% (54/119) of cervical lesion-containing tissues while it was rarely detectable (0/22) in the control specimens (P = 0.000). ROC curve analysis showed that HLA-G has an area under the curve (AUC) of 0.694. Furthermore, we investigated soluble HLA-G expression in the plasma of 172 patients with cervical lesions and 20 healthy controls. Significant increases were also observed in soluble HLA-G levels (median, 191.4 vs 45.18 U/ml, P < 0.001). The relative operating characteristic (ROC) curves for soluble HLA-G (sHLA-G), squamous cell carcinoma (SCC), and carbohydrate antigen 125 (CA125) show an AUC of 0.710, 0.634, and 0.588, respectively. At the cut-off values of 108.20 U/ml for sHLA-G, 1.5 ng/ml for SCC, and 35 U/ml for CA125, the sensitivity was 73.30%, 47.83%, and 44.83%, respectively. The detection of soluble HLA-G in plasma may have significance in the early detection of cervical malignant lesions."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0039.2010.01607.x"xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Wang L.L."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Zheng N."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Wang C.X."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Zhu C.B."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Dong Z.G."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Kan S.F."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/author | "Du L.T."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/pages | "218-224"xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/title | "Up-regulation of HLA-G expression in cervical premalignant and malignant lesions."xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/21299526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21299526 |
| http://purl.uniprot.org/citations/21299526 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21299526 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9X9-mappedCitation-21299526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21299526 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y0-mappedCitation-21299526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21299526 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y1-mappedCitation-21299526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21299526 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y2-mappedCitation-21299526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21299526 |