| http://purl.uniprot.org/citations/21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21300980 | http://www.w3.org/2000/01/rdf-schema#comment | "Oncogenic transformation of CD4(+) T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax oncoprotein, a potent transcriptional regulator. In search of novel biomarkers with relevance to oncogenesis, we identified the tumor marker and actin-bundling protein Fascin (FSCN1) to be specifically and strongly up-regulated in both HTLV-1-transformed and adult T-cell leukemia/lymphoma patient-derived CD4(+) T cells. Fascin is important for migration and metastasis in various types of cancer. Here we report that a direct link can exist between a single viral oncoprotein and Fascin expression, as the viral oncoprotein Tax was sufficient to induce high levels of Fascin. Nuclear factor-κB signals were important for Tax-mediated transcriptional regulation of Fascin in T cells. This suggests that Fascin up-regulation by Tax contributes to the development of HTLV-1-associated pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-09-305805"xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/author | "Fleckenstein B."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/author | "Kress A.K."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/author | "Grassmann R."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/author | "Kalmer M."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/author | "Rowan A.G."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/pages | "3609-3612"xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/title | "The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-kappaB signals."xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21300980 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21300980 |
| http://purl.uniprot.org/citations/21300980 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21300980 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_A0A384MEG1-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_B3KTA3-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_B3KTM9-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_Q16658-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_Q2TAM5-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_P78359-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |
| http://purl.uniprot.org/uniprot/#_Q04206-mappedCitation-21300980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21300980 |